Endocrine Abstracts

Introduction: Adrenal myelolipoma is an extremely rare benign adrenal tumor. Adrenal myelolipoma is characterized by the presence within the adrenal gland of mature adipose tissue and active bone marrow elements. Owing to their non-functional nature most cases are incidental, either at autopsy or through computer tomography scan. Occasionally the lesions attain a large size to become clinically apparent. Seropositive rheumatoid arthritis is a disorder affecting approximately 1...

Introduction: Von Hippel-Lindau (VHL) syndrome is an inherited disorder characterized by the formation of tumors and cysts in diverse organ systems. Tumors may be malignant or benign and they tend to appear during young adulthood. Hemangioblastomas are characteristic of VHL syndrome.Aim: The aim was to describe the case of a patient with VHL syndrome presenting with musculoskeletal manifestations and multiple tumors.Case report: A ...

Introduction: The 2017 WHO Classification of Pituitary Tumors grades silent corticotroph adenomas (SCAs) as high-risk adenomas due to their aggressive clinical behaviour (high probability of recurrence). Nonetheless, studies comparing recurrence rates of SCA with other non-functioning pituitary adenomas (NFPAs) subtypes have provided conflicting results necessitating review of the evidence this recommendation relies on.Aims: To estimate recurrence rates ...

Introduction: In rheumatoid arthritis (RA) glucose metabolism may be affected either by the autoimmune inflammatory disease itself, or by the treatment used to manage the disease. Metabolic syndrome seems to be prevalent in RA patients.Aim: The aim was to study the prevalence of diabetes mellitus type 2 and metabolic factors related to the development of atherosclerosis within a cohort of RA patients cared for within a single Rheumatology Department....

Background: Following pituitary surgery, dynamic testing with insulin tolerance (ITT) or glucagon stimulation testing (GST) is used to identify patients with secondary hypocortisolism who require glucocorticoids. High glucocorticoid replacement doses are associated with adverse effects, and the optimal replacement dose is unknown.Aim: We aimed to assess the interpretation of dynamic testing post pituitary surgery in clinical practice and its relation wit...

Background: After pituitary surgery patients require HPA axis assessment, that is achieved with postoperative cortisol measurements and, in selected patients whose post-operative cortisol measurements are inconclusive, with the insulin tolerance test (ITT) and the glucagon stimulation test (GST).Aim: We aimed to assess the performance of the day 2/3 post-operative cortisol in predicting the HPA axis sufficiency as assessed by the ITT and the GST.<p c...

Introduction: Betamethasone (BM) is widely used in pregnancy. Its diabetogenic potential is known, and in combination with placental insulin resistance in pregnancy, leads to a transient increase in glycemia. Our aim was to study the changes in glycemia in women with singleton pregnancies and pre-existing diabetes mellitus, under insulin therapy, after administration of BM for obstetric causes.Materials and methods: We closely monitored and assessed the ...

Introduction: Prolactinomas are rarely found in adolescents under 15 (incidence 0.1/1.000.000). They account for 50% of all types of pituitary adenomas in childhood and adolescence (2% of intracranial tumors). The mean time from onset of symptoms to diagnosis is 2.4 years on average for girls. In cases of macroadenomas, TSH and GH deficiency may coexist. The gold standard primary therapy is dopamine agonists. In case of non-response, or the presence of large prolactinomas with...

Introduction: Denosumab is a new pharmacotherapy option for postmenopausal osteoporosis. It is a human monoclonal antibody against RANKL, acting as an osteoprotegerin (OPG) analog. Recently, osteoprotegerin levels were found to be elevated in type two diabetes while insulin resistance was shown to be positively associated with decreased serum OPG levels, in healthy obese subjects. However, no study has been conducted in order to clarify the effect of anti-RANKL factors adminis...

Rheumatoid arthritis (RA) is known to be associated with cardiovascular comorbidity. In particular, patients with RA are known to be at increased for the development of atherosclerosis. Treatment with biological agents in RA may affect lipid levels.Aim: The aim was to study the effect of rituximab treatment on lipid levels in RA patients.Methods: In a cohort of 20 patients with RA lipid levels were studied before, 6 and 12 months a...